Karpenisi (Greek: Καρπενήσι – Karpenísi) is a town in central Greece. It is the capital of the peripheral unit of Evrytania. The area around Karpenisi is mountainous while farmlands are mainly in valley areas.
Karpenisi is situated in a valley area of the Karpenisiotis (Καρπενησιώτης) River, a tributary of the Achelous and the Megdova Rivers. Mount Tymfristos lies to the north elevating at nearly 2,315 m. Another mountain dominates the south. Karpenisi has a skiing resort .